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GLP-1 signaling also antagonizes voltage-dependent K + (Kv) channels via cAMP/PKA-dependent pathway in beta cells, which prevents beta-cell repolarization by reducing Kv currents

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Retatrutide holds potential for type 2 diabetes, MASH, and other persistent health conditions

EMA Paediatric Investigation Plan Decision P/0336/2024 for retatrutide

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But then there are also effects in the hindbrain and in some of the reward centers also have GLP-1 receptors