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This adaptive response typically develops within 4-6 weeks of consistent dosing

The resulting triglyceride-enriched LDL and HDL particles become ideal substrates for hepatic lipase, which hydrolyzes the triglycerides, generating sdLDL and small, dense HDL (98)

Food and Drug Administration (2025b)

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Figures 1 and 3 were modified from Servier Medical Art, licensed under a Creative Common Attribution 3.0 Generic License ( Funding This work was supported by the National Natural Science Foundation (81371215 and 81670786) and Key R&D Projects of Zhejiang Provincial Department of Science and Technology (2021 C03094)

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