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Furthermore, extreme weight loss can result in excess skin and sagging, as stretched skin loses its elasticity and cannot retract fully, much like a deflated balloon

Marketed under the brand names Mounjaro (for diabetes) and Zepbound (for weight management), tirzepatide represents a significant advancement in metabolic disease therapy through its dual incretin receptor activation

The landmark PREDIMED trial -- a randomized controlled trial involving 7,447 participants -- demonstrated that a Mediterranean diet supplemented with EVOO (approximately 50 g/day) did not result in weight gain over nearly five years of follow-up, despite being an unrestricted-calorie, high-fat diet (Estruch et al., 2018)

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