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William Castle demonstrated that gastric juice contained an "intrinsic factor" which when combined with meat ingestion resulted in absorption of the vitamin in this condition

Neurological Symptoms : Complaints of tingling, numbness in hands or feet, or difficulty walking

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Persistent neurological symptoms, fatigue, or symptom recurrence before scheduled injections warrant medical review and possible dosage adjustment

Preserved lean muscle mass while reducing fat mass Studies showed that NNMT inhibition selectively reduced adipose tissue without negative effects on skeletal muscle mass, suggesting a favorable body composition profile

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