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Another option is to use compounds that can form nontoxic complexes with Cu (II), preventing its accumulation in senile plaques and increasing its bioavailability

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Based on such evolving biology, the 3Ts protocol integrates all available therapeutic tools, pharmacologic oxygenation (tadalafil), intralesional biologic regeneration (tunneling), and mechanical remodeling (traction) to promote true tissue restoration rather than simple deformity correction (Table 1)

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