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Some formulations have also been shown to reduce cardiovascular risk and slow the progression of chronic kidney disease (CKD)

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Two main strategies have been used to modify the sequences of semaglutide and tirzepatide (red circles) and increase their bioavailability: 1) removal of the DPP-4 cleavage site, replacing alanine with an analogous molecule (-aminoisobutyric acid (Aib)), but not recognized by the enzyme

2023, www.health.harvard.edu/staying-healthy/understanding-new-weight-loss-drugs#:~:text=Two%20of%20these%20GLP%2D1.

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