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A study in transgenic animals demonstrates that selectively restoring pancreatic GLP-1Rs in GLP-1R null mice normalizes glucose tolerance in these animals suggesting that GLP-1R expression in the pancreas is sufficient to maintain normal glucose metabolism (Lamont et al., 2012)

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But studies like STEP-1 and SURMOUNT-1 show that 10-15% of people on these meds dont reach that benchmark

While its benefits are significant, proper dosing, cycling, and medical supervision are crucial to mitigate risks such as hypoglycemia or unintended tissue growth

Monitoring for gastrointestinal side effects is paramount, as both drugs commonly affect the digestive system

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