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411 On the other hand, EC can absorb serine directly or produce serine in the reaction intermediate 3-phosphoglycerate of the glycolytic pathway 412 for nucleotide biosynthesis and redox homeostasis

Glutamine catabolism produces glutamate that is converted to ornithine 404 and aspartate 397 and these generated amino acids are also involved in the proliferation of EC

Overall our study demonstrated the association between A plaques and the expression of various ferroptosis-related markers in human brain tissue and brain organoids

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CHAC1 can induce ferroptosis independently of ER stress, primarily by depleting GSH