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One thing that does seem to be clear is that staying on the drug is important if heart health is a treatment goal

All GLP-1 class drugs cause some degree of lean mass loss alongside fat loss, and this is a legitimate concern for anyone optimizing for longevity rather than just the number on the scale

Shein has become one of the worlds most popular and visible clothing brands, reaching $100 billion in sales in 2022 and appealing to consumers through cheap prices and influencer marketing

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Study after study has shown that older adults who carry a few extra pounds even enough to kick their BMIs into the overweight category tend to be healthier than those who are underweight

TD Cowen analyst Steve Scala has flagged the high rate of discontinuation as a concern and suggested it could make outcomes of future trials harder to predict