GLP-1 RAs not only ameliorate insulin resistance and microvascular injury [84], which are significant determinants of depression in T2DM, but also enhance dopamine metabolism and stimulate growth factor signaling pathways, suggesting potential neuroprotective functions [85,86]
Which one do we choose
Keep reading to find out what you may experience when taking a GLP-1 to lose weight or manage your type 2 diabetes, how common the side effects are, and what steps you can take to help minimize them
the tolerable upper limit from supplements alone is 350 mg/day, above which loose stools are the usual result (NIH Office of Dietary Supplements)
GI side effects (nausea) may begin
administration and observed a half-life of 1.9 h for GLP-1MK-801, which is longer than the parent GLP-1 analogue, but comparable to that of the GLP-1inactive MK-801 conjugate (Fig