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[1] It is suggested that delayed processing of secreted lipids in the interfollicular epidermis and between the corneocytes in the upper parts of the hair follicles may be the cause of an impairment in the permeability of the epithelial barrier/Lipid Lamellae

Other gauges may also be acceptable

What happens when the shortage ends

Cleveland Clinic resources (updated 2025) caution that efficacy claims lack robust RCTs and that purity varies substantially across formulations (1050% active in products)

This suggests the reaction may be more closely associated with the cagrilintide component