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Este resultado contrasta con lo que se esperara segn la literatura cientfica, que destaca la importancia del ejercicio regular y las intervenciones sostenidas para mantener la prdida de peso a largo plazo

Common gastrointestinal side effects include: Nausea and vomiting Diarrhoea or constipation Abdominal pain and bloating Reduced appetite Indigestion These effects typically diminish as the body adjusts to the medication, usually within several weeks

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A typical pattern involves 4 to 6 weeks of daily administration followed by 2 to 4 weeks off

Relatively high succinate levels lead to inhibition of the 2-oxoglutarate (2-OG)-dependent hypoxia-inducible factor (HIF) prolyl-hydroxylases, stabilising HIF-2\(\alpha \) in normoxic (or normal oxygen tensions) conditions leading to a pseudo-hypoxic state with metabolic consequences resembling those seen in cancer described as the Warburg effect (or the so-called aerobic glycolysis) a hallmark of phaeochromocytomas Kluckova and Tennant (2018)

We note that in our July 2024 Overall Hospital Quality Star Rating simulated results, hospitals with these characteristics were less likely to observe a change in their rating through Stage 1 and Stage 2 compared to their counterparts (90 FR 33787)