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Discontinue GTE if ALT or AST exceeds 1.5 times the upper limit of normal (a more conservative threshold than the iPLEDGE hold criteria, given the additive exposure)

However, the specific oral bioavailability percentage, the plasma concentration-time profile, and whether enteric coating meaningfully changes these parameters have not been published in human pharmacokinetic studies

These differences in bacterial response may be influenced by factors such as cell wall structure, antioxidant capacity, and pH tolerance

However, for some individuals with residual absorption capabilities, high-dose oral supplements can serve as an alternative

Mol Cell Biochem 478 , 949966 (2023)

Consistent with these findings, another study reported a positive association between free glutamine levels in human milk and infant length at 4 months of age (65)