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For high-risk patients, especially those with pre-existing dermatologic conditions, close monitoring is recommended to detect skin-related AEs early and allow for timely intervention

Continued treatment should maintain the metabolic advantages that produced initial weight loss

Midlife weight gain is often driven by measurable hormonal and metabolic shifts: declining testosterone or estrogen, rising cortisol, insulin resistance, thyroid dysfunction, or disrupted sleep architecture

J Biol Chem 277 (51): 49446

[13] Biosynthesis has been detected in Actinomycetota, such as Mycobacterium smegmatis and certain fungi, such as Neurospora crassa (red bread mold) [3] and Schizosaccharomyces pombe (fission yeast)

Five years after treatment or remission is used as a conservative review window rather than a proven biological cutoff