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73,74 Elevated circulating BCAAs have been detected in nonalcoholic fatty liver disease (NAFLD)

Mechanism: VEGF upregulation drives new blood vessel formation around damaged joints

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Additionally, a meta-analysis of multiple randomized, controlled trials confirmed that tesamorelin treatment significantly lowered visceral fat area and trunk fat, reduced hepatic fat, and was associated with a statistically significant increase in lean body mass, supporting its clinical effect on fat distribution and muscle preservation

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Studies have shown that APC transporter proteins play a role in protecting tumor cells by actively transporting intracellular toxic substances or drugs to the extracellular compartment, thereby contributing to chemoresistance (70,71)