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Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, Shimamoto K, Horio Y (2010) Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure

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This unexpected double-strand break not only may randomly damage functional genes, trigger cell apoptosis or functional disorders, but also may cause large-scale chromosomal translocations or rearrangements through incorrect DNA repair mechanisms, significantly increasing genomic instability

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