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Any part of the oral mucosa may be affected, but particularly the buccal mucosa, and although they are usually solitary, there are sometimes several oral melanotic macules

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10.1093/eurheartj/ehy799 111 WangZ.KlipfellE.BennettB

The antioxidant properties of lipoic acid come from its ability to directly scavenge ROS, its metal-chelating activity, and its potential to react with and promote regeneration of other antioxidants such as glutathione and vitamins E and C

These risks primarily involved the digestive system and included nausea and vomiting, stomach pain, heartburn and gastroparesis, or stomach paralysis