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First, when methionine input rises dramatically, so does [SAM] and SAM inhibits MTHFR

Some tips to get you through the transitional period when starting B12 therapy include: Resting more until the fatigue and flu-like feelings pass

To study serum iron levels in patients of gall bladder stone disease and to compare with healthy individuals

Wang T-Y, Wang H-W, Jiang M-Y

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The same applies if your elevated B12 is accompanied by abnormal results on other labs (liver enzymes, kidney markers, CBC), or by symptoms like unexplained weight loss, persistent fatigue, abdominal pain, or easy bruising