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The authors proposed multiple potential mechanisms including interactions with opioid, GABAergic, and monoaminergic systems, establishing the conceptual framework for subsequent mechanistic research into DSIP's neurophysiological actions

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Kleinkauf-Rocha J, Bobermin LD, Machado Pde M, Gonalves CA, Gottfried C, Quincozes-Santos A

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AMG 133 functionally inhibits GIP signalling through human and cynomolgus monkey GIPR with similar potency (half maximal inhibitory concentration (IC 50 ) of 42.4 nM and 26.5 nM, respectively), whereas it has more than 20-fold lower potency for inhibition of GIP signalling through rat GIPR (IC 50 = 822 nM) and did not fully antagonize mouse GIPR with concentrations of up to 3 M