This chronotropic effect, consistent with GLP-1 and glucagon receptor activation, averaged 5-10 beats per minute at peak and returned toward baseline by 48 weeks
Alexander Shapsis, regarding your health
Key Takeaways Phase 2 retatrutide reduced mean systolic blood pressure by approximately 7-8 mmHg at top doses over 48 weeks Diastolic blood pressure dropped by approximately 2-4 mmHg Placebo arm BP changes were minimal, so the active-versus-placebo gap is real and meaningful The effect tracks with weight loss, suggesting most of the benefit is downstream of weight reduction rather than a direct vascular drug effect Patients on antihypertensive medications often need dose reductions as weight loss progresses to avoid excessive BP drops Direct answer Yes
GLP-1 is one of the most transformative therapies in modern medicine, she says, though she notes the drugs are not for everyone
The literature search and data extraction were performed by the authors
In a recent case series, individuals who combined GLP-1 therapy with resistance training and adequate protein intake were able to preserve lean mass during significant weight loss
