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In cellular models of overexpressing mutant huntingtin, liraglutide has been shown to restore insulin signaling, activate AMPK, enhance autophagy, and reduce protein aggregation

Experts believe that the efficacy of these drugs in reducing the risk of depression lies in reducing inflammation, as inflammatory responses and immunity are critical in the development and onset of depression

Clinical Trial Results: Weight Loss & Key Outcomes Phase 2 (Published in NEJM & Nature Medicine) Obesity trial (NEJM 2023): Up to 24.2% mean weight loss at 48 weeks (12 mg dose)

Body fat percentage: Higher visceral fat increases somatostatin tone, which suppresses GH pulsatility

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