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Clinical data from GLP-1 trials shows that 50% of participants see at least 5% body weight loss by week 6, marking a psychological turning point where progress becomes visible and motivating

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Energy availability is lower, recovery capacity is often reduced, and the priority shifts from "burn more calories" to "send the strongest possible signal to preserve muscle" with the least metabolic cost

High-performance Liquid Chromatography Analysis A LaChrom ELITE system (Hitachi High-Tech Corporation, Tokyo, Japan) was used for the high-performance liquid chromatography (HPLC) analysis, with a L2100 pump, L2200 autosampler, L2300 column oven, and L2455 detector

10.1186/s13287-015-0013-5 5 Alcayaga-MirandaF.GonzlezP