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16, 17 In addition, in cultured vascular smooth muscle cells (VSMCs) and isolated arteries from hypertensive rats and humans, ROS production is enhanced, redox-dependent signaling is amplified, and antioxidant bioactivity is reduced

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Importantly, even in the absence of full caspase activation, BAX/BAK-mediated membrane permeabilization can still cause mtDNA leakage and trigger inflammatory responses [79]

[1] Situations Warranting Routine Follow-Up Schedule an appointment within several days if: increased urination persists beyond 4-6 weeks without improvement

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