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Thus, the application of the well-known symbiotic, ISR-inducing rhizobacterium Pseudomonas fluorescens to the phyllosphere of an apple scab-susceptible apple ( Malus domestica ) cultivar led to the up-regulation of genes encoding proteins participating in pathogen recognition, signaling and antimicrobial defense such as PR-proteins, thioredoxin-like proteins, heat shock proteins and a GST (Krkcoglu et al., 2007)

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We therefore turned our efforts towards finding a new crystal system that could accommodate larger ligands in the TIN2 TBM binding site, and where the binding mode of ligands would not be influenced by a neighbouring TRF1 TRFH molecule in the crystal packing arrangement

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