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According to the National Institute on Drug Abuse (NIDA) in their publication Understanding Drug Use and Addiction in 2020, environmental stressors and social dynamics play a pivotal role in the development of substance use disorders

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Adipose tissue in insulin-resistant states releases increased free fatty acids and inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6, which interfere with insulin signaling pathways at the cellular level

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