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It was found that the binding of all the phytochemicals induce a higher fluctuation in the distant regions from the active site, especially in the region post 400 residue number (Fig

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In susceptible patients, these pressures may increase mitochondrial stress, raise SAH, lower the SAM-to-SAH ratio and create a functional undermethylation pattern that contributes to depression, anxiety, brain fog, fatigue and medication sensitivity

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