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In animal models, intra-articular administration of liraglutide reduced the secretion of inflammatory cytokines such as IL-6, the expression of inflammatory genes in chondrocytes, the amount of proinflammatory M1 macrophages, and improved pain-related behaviors 104

Moreover, the mannose glycosylated hybrid micellar DAS-MMic that specifically delivers dasatinib (DAS) can also selectively reduce the number of M2-type TAMs thereby reshaping the immunosuppressive tumor microenvironment and ultimately inhibiting tumor progression (25)