Inoue M, Hara M, Nagashima F, Matsui S, Mitsuyasu N, Morino Y: Affinity chromatography of hepatic glutathione S-transferases on omega-aminoalkyl sepharose derivatives of glutathione
Lipofuscin is another pigment which increases in the myocardium, skeletal muscle, liver etc with increasing age.1 Lipofuscin is biochemically distinct from melanin and shows a characteristic autofluorescence.2 Non-aged related deposition of lipofuscin occurs in the melanosis coli (so-called "brown bowel syndrome") as described below, as well as in many other organs, such as the thyroid, oesophagus, and the gall bladder.1 This condition, whereby the normal pinkish colonic mucosa became diffusely infiltrated by dark pigmentation, was described as early as 1825
JAMA 314(8):791801
The Peroxisome proliferator activated receptor (PPAR) is a master transcriptional regulatory factor, where PPAR- manipulates the transport activity of FA (CD36) and LC (organic cation transporter novel 2, OCTN2) (Leonardsson et al., 2004
Of note, the researchers of this study discovered that the structure of the food sources did not impact the delivery of nutrients or the release of gut peptides
Circulation 132 , e120 (2015)
