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Given the importance of ACh and Ca 2+ signalling in immune cell function, the impaired immune cell function and sensitivities reported by patients with ME/CFS to environmental irritants suggest dysfunction of AChRs channels in ME/CFS, for which there is clear and growing evidence

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These serve as messengers to the body and instruct the cells to carry out specific actions such as repairing tissue, synthesizing collagen, or triggering growth