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Similarly, in SURMOUNT-4 (tirzepatide), participants completed a 36-week open-label lead-in to 10 or 15 mg, after which they were randomized to continue tirzepatide or switch abruptly to placebo

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Both GLP-1 and exendin-4 control blood glucose through the stimulation of glucose-dependent insulin secretion, the inhibition of glucagon secretion, and delayed gastric emptying [34, 46, 47], which facilitate the decrease in blood glucose in type 1 and type 2 diabetic patients [48]

Lifestyle Considerations: Both Semaglutide and Tirzepatide require a commitment to healthy lifestyle practices, including a balanced diet and regular physical activity

A pharmaceutical composition according to any one of embodiments 1-50 for use as a medicament