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What to Do If Once-Weekly Semaglutide Isn't Delivering Results If you've been on semaglutide for at least eight weeks and notice stalled weight loss or inadequate appetite suppression, the first step is to confirm you've reached your current therapeutic dose level

lifestyle factors such as diet, physical activity, and sleep

By understanding how your genetics, including specific variants in the GLP1R and GIPR genes, and other factors impact your likelihood, you can work with your clinician to manage potential side effects

Common side effects include nausea, vomiting, and diarrhea

Specifically, 72 weeks of once-weekly injectable tirzepatide (5 mg, 10 mg, or 15 mg) resulted in a significant reduction in body weight among participants whose average weight was 104.8 kg (over 230 lb)