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Allosteric modulation of endogenous metabolites as an avenue for drug discovery

However, no stable differences were observed for HOMA-IR or total cholesterol, suggesting that while benefits for weight, lipid metabolism, and androgens are relatively consistent, the IR endpoint may be more heavily influenced by sample size, follow-up duration, and baseline IR severity

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Nausea was the most common side effect associated with pramlintide, but it was generally mild to moderate and occurred in less than 10% of participants during the extension phase

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They attempt to boost metabolism or block fat absorption