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Its use is limited by a broad side-effect profile, including anticholinergic effects (e.g., dry mouth, urinary retention), sedation, and orthostatic hypotension

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Structural insights into the mechanism of four-coordinate cob(II)alamin formation in the active site of the salmonella enterica ATP: Co(I)crinoid adenosyltransferase enzyme: Critical role of residues Phe91 and Trp93