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Bishop CR, Yan K, Nguyen W, Rawle DJ, Tang B, Larcher T, et al

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In addition, various other nanoparticles have also been shown to improve the immunosuppressive tumor microenvironment by reducing MDSCs infiltration or decreasing MDSCs activity, such as high-density lipoprotein-like nanoparticles (HDL-NP) can specifically target the high-affinity receptor B-1 scavenger receptor (SCARB1) of spherical high-density lipoprotein (HDL) expressed by MDSCs thereby inhibiting MDSCs activity and enhancing the immune response to cancer and significantly inhibiting tumor growth (131)

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10.1158/0008-5472.CAN-12-3150 [DOI] [PMC free article] [PubMed] [Google Scholar] Bersuker K., Hendricks J

Its mechanism of action involves the direct inhibition of the transcription factor NF-B, a central regulator of the inflammatory response