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In addition, the exosome of CAFs, LINC01614, has been demonstrated to directly interact with ANXA2 and p65, thereby promoting NF-B activation

Note that these changes come at the expense of the photosynthetic function of chloroplasts, including global down-regulation of photosynthetic genes, photoinhibition, and damage of photosystem II (PSII), which are essential for chloroplast immunity 20,21,22,23,24

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Animal studies are also included in this table and clearly identified as such

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Feeding mice with the KD resulted in a noteworthy decrease in the expression of immune inhibitory receptors (PD-1 and CTLA-4) on CD8 + TILs, as well as a reduction in the expression of inhibitory ligands (CD86 and PD-L1) on cancer cells