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If drugs to mitigate nausea (or other GI AEs) are needed for over a month when the maintenance GLP-1 RA dose has been reached, a dose reduction should be considered for the patient to tolerate the drug with no need for pharmacological support [35]
Subcutaneous or intranasal administration bypasses hepatic metabolism, meaning a 1mg intranasal dose may produce plasma concentrations equivalent to 22.5mg oral
G.MotaM
These platforms improve intra-articular retention, enhance drug bioavailability, and allow localized release of antioxidants, growth factors, or small-molecule inhibitors precisely within inflamed or mechanically stressed regions of the joint (Yin et al., 2024
This is too aggressive for daily GLP-1 support and can cause water retention and bloating