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Unexpectedly, and in contrast to observations in fibroblasts, ACLY and ACSS2 double knockout (DKO) cancer cells remain viable and proliferate, maintain pools of cytosolic acetyl-CoA, and are competent to acetylate proteins in both cytosolic and nuclear compartments
Zhou Q, Verne ML, Fields JZ, Lefante JJ, Basra S, Salameh H, et al
None known to this date
To keep the benefits going, we may suggest a schedule or add-ons like intramuscular injections that help with maintenance between drips
From a translational perspective, this raises the possibility that combined modulation of these pathways could stabilize the neurovascular unit and preserve cerebral homeostasis
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