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In addition to the remaining ACE2 expression, another possible explanation for this heterogeneity in COVID-19 susceptibility could be that that independently of ACE2, the quality of life for people with cystic fibrosis may depend on contributions from non-CFTR modifier or bystander genes 69,70,71,72,73,74,75

For example, the combination of alcohol and barbiturates amplify the CNS depressant effect which is why it is easy to overdose on this combination

Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review

However, clinically successful treatment strategies are still lacking and are often inspired by treatment options for diseases with similar clinical presentations, such as ME/CFS

doi: 10.1016/j.exphem.2023.08.001 55 JamrusP.PholngamN.KiatpakdeeB.ViwatpinyoK.VadolasJ.NgampramuanS.et al

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