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Such a trial would likely take several years and cost tens of millions of dollars, but the potential payoff, a new treatment option for a condition that affects over a billion people worldwide, justifies the investment

Physicians also screen for exclusion criteria including pregnancy plans, certain gastrointestinal conditions, and drug interactions that could affect safety or efficacy

Diabetes Care 2009;32:12371243

The efflux liability for both compoundseach being a P-glycoprotein substrate (Table 4)suggests that co-administration with efflux inhibitors might enhance systemic exposure, an approach under active investigation for overcoming chemotherapy resistance 69

In future, precise genetic polymorphic screening tests may play a more central role in determining chemotherapeutic treatment regimens for patients