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The clinical trials that led to FDA approval demonstrated consistent reductions in visceral adipose tissue, measured by imaging

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Changes in the levels of both circulating biomarkers were correlated with the TMAO levels (rho = 0.568, p = 0.002

Receptor-Binding Studies: Employed to evaluate peptide-receptor affinity, ligand specificity, and downstream signaling activation in receptor-focused research models

In contrast, immune signaling in the TG was largely resolved, while OXPHOS and mitophagy pathways were upregulated, indicating a regenerative mitochondrial response ( Figure 3B