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Novo Nordisk reined in its growth forecasts for the year in its second-quarter financial results update, blaming "persistent use of compounded GLP-1s, slower-than-expected market expansion, and competition." Compounding of semaglutide should have come to a halt in the US since the drug was removed from the FDA list of medicines in short supply, but various companies continue to provide compounded GLP-1s under a loophole that allows the sale of 'personalised' formulations

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Clinical and observational data describe: Modest reductions in body fat percentage over typical protocol durations (often 36 months) Preservation or modest gains in lean body mass Reductions in visceral adipose tissue, as measured in some imaging-based studies Subjective improvements in recovery and sleep quality Realistic magnitude

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