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1170 HK, the enzyme that initiates glycolysis through glucose phosphorylation, is competitively inhibited by 2-deoxyglucose (2-DG), which structurally resembles glucose and binds to HK2, thereby hindering its activity through the accumulation of phosphorylated 2-DG

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This forms the basis for NICE recommendations that weight management should be a first-line intervention for individuals with obesity who are experiencing fertility difficulties

This medication is a tool to help manage blood sugar, but it works best as part of a comprehensive lifestyle change

Semaglutide commonly causes gastrointestinal side effects including nausea, vomiting, and diarrhea, particularly during dose escalation