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This level declines to roughly 80 ng/mL by age 60, a reduction that correlates with diminished regenerative capacity and accelerated aging at the tissue level

However, a lack of GLP-1R is also observed to trigger a stress response that boosts fibroblast growth factor 21 and elicits beneficial systemic effects such as memory improvement and glucose homeostasis (Timper et al., 2020)

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