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However, when intracellular iron ions are overloaded, Fe 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Ingold et al., 2018) (Figure 4)

Myogenic differentiation quantified through real-time PCR showing increased MyoD and myogenin expression

AOD9604 alone significantly improved both gross morphological and histopathological cartilage scores versus saline controls, and the combination of AOD9604 with hyaluronic acid produced superior outcomes to either agent administered alone including significantly shorter lameness periods

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and gut-barrier signalling

Peripheral is central to the question