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One potential mechanism is the Nrf2-ARE pathway, which induces a phase 2 detoxification response that promotes disruption of Nrf2-Keap protein interactions, translocation of Nrf2 to the nucleus, and regulation of target gene expression through the ARE, enhancing cellular defense against oxidative damage (Sharma et al., 2010)

Dr McBride, Professor of Pediatrics at Department of Pediatrics, Northeast Ohio Medical University, Rootstown, Ohio summarizes the evidence for the acetaminophen asthma findings: There remains a possibility that confounding variables might explain some or all of the association between acetaminophen and asthma

Once absorbed, intracellular enzymes remove the acetyl group, releasing active reduced glutathione inside the cell

126 TrachoothamD.ZhouY.ZhangH.DemizuY.ChenZ.PelicanoH.et al (2006)

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