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However, they did not consistently improve psychiatric symptoms or cognitive function in these patients

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Although the use of traditional medications, DMARDs, and innovative biologic agents has collectively improved treatment outcomes, numerous patients exhibit insufficient responses to existing therapies or adverse side effects, highlighting the necessity for novel treatment strategies (176)

In the Sema/HFD group, the most enriched GO terms of BP, MF, and CC were annotated as immune effector process, signaling receptor activity, and extracellular region part, respectively ( Figures 5C, D , Table 3 )

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