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Certain medical conditions, as well as a family history of certain conditions, are potential contraindications of semaglutide that can increase the risk of side effects

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The dual-receptor activation that makes tirzepatide effective for weight loss also stimulates nausea and vomiting in some patients, which can trigger or worsen headaches through dehydration and electrolyte shifts

doi: 10.1055/s-0038-1646947 4

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Key players and recent deals: Innovent Biologics : Mazdutide (GLP-1R/GCGR dual) approved June 2025 in China Gan & Lee : Bofanglutide (biweekly) Phase 3 extension