In this pathway, the protein Ub, belongs to a family of heat shock proteins (HSPs), is covalently bound by thiol groups to misfolded or damaged proteins and contributes in their breakdown by transferring them to the protease 26S complex
Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewings sarcoma: a phase 1 expansion cohort study
However, further study is needed to eliminate confounding factors
Still, in general, an overdose will cause confusion and disorientation, profoundly slowed breathing and heart rate, and can result in heart arrhythmia, heart attack, or respiratory arrest that leads to brain damage or death
Further studies are underway to explore its potential benefits in these areas
All published data till the year 2025 have been taken into consideration