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This finding was further validated by the absence of blood glucose changes in wild-type mice following the administration of exendin 2029 at effective doses, in contrast with the hypoglycemic effect observed with exendin-4

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Doctors adjust dosing all the time based on individual patient needs

The pharmaceutical agents can produce 15-20% body weight reduction in clinical trials

Despite demonstrating robust glycemic efficacy, both agents were eventually discontinued due to distinct tolerability and safety concerns, diverging in severity and clinical implications

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