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FDA issued a total of 303 warning letters (WLs) to drug and biologics products in Fiscal Year 2025 (FY25), a 59% increase from FY24 (190)

Circadian homeostasis of liver metabolism suppresses hepatocarcinogenesis

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This uncertainty likely reflects the tight interdependence of mitochondrial integrity and inflammatory signaling, which form self-reinforcing feedback loops, together with technical limitations in longitudinal in vivo assessment, particularly in human studies

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